Fibroblast is the cover term for cells which are of mesenchymal origin and are located in connective tissue. They play an important role in the synthesis of intercellular substance, the extracellular matrix. Collagen is one of the major fibroblast products and, together with contemporaneously formed proteoglykanes, provides for enhanced strength of the extracellular matrix. Damage to tissue is capable of stimulating proliferation of fibroblasts and increasing discharge of cytokines which have a positive impact on repair of such damage.